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4-hydroxyphenylacetate degradation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(4Z)-2-oxohept-4-enedioate + H2O <=> (4S)-4-hydroxy-2-oxoheptanedioate 4.2.1
4.2.1.163 2-oxo-hept-4-ene-1,7-dioate hydratase


(4S)-4-hydroxy-2-oxoheptanedioate <=> succinate_semialdehyde + pyruvate 4.1.2.20 2-dehydro-3-deoxyglucarate aldolase
4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
4.1.3.39 4-hydroxy-2-oxovalerate aldolase



5-Carboxymethyl-2-hydroxymuconate <=> (3E,5R)-5-carboxy-2-oxohept-3-enedioate 5.3.3.10 5-carboxymethyl-2-hydroxymuconate Delta-isomerase

4-hydroxyphenylacetate + O2 + FADH2 <=> H+ + 3,4-Dihydroxyphenylacetate + H2O + FAD 1.14.14.9 4-hydroxyphenylacetate 3-monooxygenase

5-carboxymethyl-2-hydroxymuconate_semialdehyde + NAD+ + H2O <=> H+ + 5-Carboxymethyl-2-hydroxymuconate + NADH 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
1.2.1.60 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase


H+ + (3E,5R)-5-carboxy-2-oxohept-3-enedioate <=> (4Z)-2-oxohept-4-enedioate + CO2 4.1.1.68 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase

O2 + 3,4-Dihydroxyphenylacetate <=> H+ + 5-carboxymethyl-2-hydroxymuconate_semialdehyde 1.13.11.15 3,4-dihydroxyphenylacetate 2,3-dioxygenase

succinate_semialdehyde + NADP+ + H2O <=> NADPH + succinate + H+ 1.1.1.21 aldose reductase
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+)





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